Cellular and synaptic network defects in autism
نویسندگان
چکیده
منابع مشابه
Cellular and synaptic network defects in autism.
Many candidate genes are now thought to confer susceptibility to autism spectrum disorders (ASDs). Here we review four interrelated complexes, each composed of multiple families of genes that functionally coalesce on common cellular pathways. We illustrate a common thread in the organization of glutamatergic synapses and suggest a link between genes involved in Tuberous Sclerosis Complex, Fragi...
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All network dynamics emerge from the complex interaction between the intrinsic membrane properties of network neurons and their synaptic connections. Nervous systems contain numerous amines and neuropeptides that function to both modulate the strength of synaptic connections and the intrinsic properties of network neurons. Consequently network dynamics can be tuned and configured in different w...
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Autism has been shown to have a major genetic risk component; the architecture of documented autism in families has been over and again shown to be passed down for generations. While inherited risk plays an important role in the autistic nature of children, de novo (germline) mutations have also been implicated in autism risk. Here we find that autism de novo variants verified and published in ...
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The membrane properties and the synaptic interactions of individual neurons, as well as the interactions between neuronal networks, all contribute to the formation of the complex patterns of activity that underlie rhythmic motor patterns and slow-wave sleep rhythms. These properties and interactions are potential points of modulation for further refining network output. Recent work illustrates ...
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ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2012
ISSN: 0959-4388
DOI: 10.1016/j.conb.2012.02.015